Regulation of gene expression in the brain by sex hormones

Sun, SD, Tollkuhn, J (January 2023) Regulation of gene expression in the brain by sex hormones. In: Principles of Gender-Specific Medicine: Sex and Gender-Specific Biology in the Postgenomic Era. UNSPECIFIED, pp. 117-127. ISBN 9780323885348

DOI: 10.1016/B978-0-323-88534-8.00009-2


The mammalian nervous system exhibits sexual variability in neural anatomy and activity, which contributes to sex differences in behavior. Importantly, changes are seen in both space and time as sex variability appears and diminishes at various life stages. These spatiotemporal dynamics are in part controlled by gonadal hormones, which coordinate gene expression. Many of these differences arise during critical periods of development, where early-life hormones are thought to irreversibly establish developmental trajectories. This hypothetical framework arose from the study of sexually biased behaviors that depend on neonatal exposure to sex hormones, namely estradiol and testosterone. As such, many physiological and behavioral differences are linked to gonadal hormone regulation of gene expression. However, despite over a decade of study, only a small number of genes controlled by sex hormones have been identified and replicated. This is due to several complicating factors such as the highly specialized nature of neural tissues and their constitutive cellular profiles. In this chapter, we discuss the new conceptual and technological advances that have enabled researchers to investigate the molecular underpinnings of sex variability in neuronal gene expression.

Item Type: Book Section
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > hormones
organism description > animal > mammal
organism description > animal behavior > sex differences
CSHL Authors:
Communities: CSHL labs > Tollkuhn lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 1 January 2023
Date Deposited: 22 Sep 2023 14:13
Last Modified: 22 Sep 2023 14:13
Related URLs:

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving