Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Szadai, Zoltán, Pi, Hyun-Jae, Chevy, Quentin, Ócsai, Katalin, Albeanu, Dinu F, Chiovini, Balázs, Szalay, Gergely, Katona, Gergely, Kepecs, Adam, Rózsa, Balázs (November 2022) Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment. eLife, 11. e78815. ISSN 2050-084X

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Abstract

Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward and punishment are represented in local cortical computations. Previously, we identified a cortical neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, in auditory cortex that is recruited by behavioral reinforcers and mediates disinhibitory control by inhibiting other inhibitory neurons. As the same disinhibitory cortical circuit is present virtually throughout cortex, we wondered whether VIP neurons are likewise recruited by reinforcers throughout cortex. We monitored VIP neural activity in dozens of cortical regions using three-dimensional random access two-photon microscopy and fiber photometry while mice learned an auditory discrimination task. We found that reward and punishment during initial learning produce rapid, cortex-wide activation of most VIP interneurons. This global recruitment mode showed variations in temporal dynamics in individual neurons and across areas. Neither the weak sensory tuning of VIP interneurons in visual cortex nor their arousal state modulation was fully predictive of reinforcer responses. We suggest that the global response mode of cortical VIP interneurons supports a cell-type-specific circuit mechanism by which organism-level information about reinforcers regulates local circuit processing and plasticity.

Item Type:	Paper
Subjects:	Investigative techniques and equipment organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex Investigative techniques and equipment > microscopy > flourescence microscopy organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organism description > animal > mammal Investigative techniques and equipment > microscopy organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent Investigative techniques and equipment > microscopy > flourescence microscopy > two-photon excitation microscopy
CSHL Authors:	Pi, Hyun Jae Chevy, Quentin Albeanu, Dinu F. Kepecs, Adam
Communities:	CSHL labs > Albeanu lab CSHL labs > Kepecs lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	23 November 2022
Date Deposited:	29 Nov 2022 16:53
Last Modified:	17 Jan 2024 15:36
PMCID:	PMC9683790
URI:	https://repository.cshl.edu/id/eprint/40764

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