Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

Szadai, Zoltán, Pi, Hyun-Jae, Chevy, Quentin, Ócsai, Katalin, Albeanu, Dinu F, Chiovini, Balázs, Szalay, Gergely, Katona, Gergely, Kepecs, Adam, Rózsa, Balázs (November 2022) Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment. eLife, 11. e78815. ISSN 2050-084X

[thumbnail of 2022-Kepecs-Cortex-wide-response-mode-of-VIP-expressing-inhibitory-neurons-by-reward-and-punishment.pdf] PDF
2022-Kepecs-Cortex-wide-response-mode-of-VIP-expressing-inhibitory-neurons-by-reward-and-punishment.pdf
Available under License Creative Commons Attribution.

Download (7MB)
URL: https://www.ncbi.nlm.nih.gov/pubmed/36416886
DOI: 10.7554/eLife.78815

Abstract

Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward and punishment are represented in local cortical computations. Previously, we identified a cortical neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, in auditory cortex that is recruited by behavioral reinforcers and mediates disinhibitory control by inhibiting other inhibitory neurons. As the same disinhibitory cortical circuit is present virtually throughout cortex, we wondered whether VIP neurons are likewise recruited by reinforcers throughout cortex. We monitored VIP neural activity in dozens of cortical regions using three-dimensional random access two-photon microscopy and fiber photometry while mice learned an auditory discrimination task. We found that reward and punishment during initial learning produce rapid, cortex-wide activation of most VIP interneurons. This global recruitment mode showed variations in temporal dynamics in individual neurons and across areas. Neither the weak sensory tuning of VIP interneurons in visual cortex nor their arousal state modulation was fully predictive of reinforcer responses. We suggest that the global response mode of cortical VIP interneurons supports a cell-type-specific circuit mechanism by which organism-level information about reinforcers regulates local circuit processing and plasticity.

Item Type: Paper
Subjects: Investigative techniques and equipment
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organism description > animal
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
Investigative techniques and equipment > microscopy > flourescence microscopy
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organism description > animal > mammal
Investigative techniques and equipment > microscopy
organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions
organism description > animal > mammal > rodent
Investigative techniques and equipment > microscopy > flourescence microscopy > two-photon excitation microscopy
CSHL Authors:
Communities: CSHL labs > Albeanu lab
CSHL labs > Kepecs lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 23 November 2022
Date Deposited: 29 Nov 2022 16:53
Last Modified: 17 Jan 2024 15:36
PMCID: PMC9683790
URI: https://repository.cshl.edu/id/eprint/40764

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving