Cystatin C is associated with adverse COVID-19 outcomes in diverse populations

Kleeman, Sam O, Cordioli, Mattia, Timmers, Paul RHJ, Khan, Atlas, Tober-Lau, Pinkus, Kurth, Florian, Demichev, Vadim, Meyer, Hannah V, Wilson, James F, Ralser, Markus, Kiryluk, Krzysztof, Ganna, Andrea, Baillie, Kenneth, Janowitz, Tobias (October 2022) Cystatin C is associated with adverse COVID-19 outcomes in diverse populations. iScience, 25 (10). p. 105040. ISSN 2589-0042 (In Press)

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DOI: 10.1016/j.isci.2022.105040


COVID-19 has highly variable clinical courses. The search for prognostic host factors for COVID-19 outcome is a priority. We performed logistic regression for ICU admission against a polygenic score (PGS) for Cystatin C (CyC) production in patients with COVID-19. We analyzed the predictive value of longitudinal plasma CyC levels in an independent cohort of patients hospitalized with COVID-19. In four cohorts spanning European and African ancestry populations, we identified a significant association between CyC-production PGS and odds of critical illness (n cases=2,319), with the strongest association captured in the UKB cohort (OR 2.13, 95% CI 1.58-2.87, p=7.12e-7). Plasma proteomics from an independent cohort of hospitalized COVID-19 patients (n cases = 131) demonstrated that CyC production was associated with COVID-specific mortality (p=0.0007). Our findings suggest that CyC may be useful for stratification of patients and it has functional role in the host response to COVID-19.

Item Type: Paper
Subjects: diseases & disorders > viral diseases > coronavirus > covid 19
CSHL Authors:
Communities: CSHL Cancer Center Program
CSHL Cancer Center Program > Cancer Genetics and Genomics Program
CSHL labs > Janowitz lab
CSHL labs > Meyer Lab
School of Biological Sciences > Publications
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: October 2022
Date Deposited: 15 Sep 2022 21:23
Last Modified: 29 Feb 2024 17:09
PMCID: PMC9428108

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