Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms

Rupert, Deborah D, Shea, Stephen D (May 2022) Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms. Frontiers in Neural Circuits, 16. p. 886629. ISSN 1662-5110

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Abstract

Parvalbumin-positive neurons are the largest class of GABAergic, inhibitory neurons in the central nervous system. In the cortex, these fast-spiking cells provide feedforward and feedback synaptic inhibition onto a diverse set of cell types, including pyramidal cells, other inhibitory interneurons, and themselves. Cortical inhibitory networks broadly, and cortical parvalbumin-expressing interneurons (cPVins) specifically, are crucial for regulating sensory plasticity during both development and adulthood. Here we review the functional properties of cPVins that enable plasticity in the cortex of adult mammals and the influence of cPVins on sensory activity at four spatiotemporal scales. First, cPVins regulate developmental critical periods and adult plasticity through molecular and structural interactions with the extracellular matrix. Second, they activate in precise sequence following feedforward excitation to enforce strict temporal limits in response to the presentation of sensory stimuli. Third, they implement gain control to normalize sensory inputs and compress the dynamic range of output. Fourth, they synchronize broad network activity patterns in response to behavioral events and state changes. Much of the evidence for the contribution of cPVins to plasticity comes from classic models that rely on sensory deprivation methods to probe experience-dependent changes in the brain. We support investigating naturally occurring, adaptive cortical plasticity to study cPVin circuits in an ethologically relevant framework, and discuss recent insights from our work on maternal experience-induced auditory cortical plasticity.

Item Type:	Paper
Subjects:	bioinformatics bioinformatics > genomics and proteomics > small molecules > GABA bioinformatics > genomics and proteomics organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons bioinformatics > genomics and proteomics > small molecules
CSHL Authors:	Rupert, Deborah D. Shea, Stephen D.
Communities:	CSHL labs > Shea lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	6 May 2022
Date Deposited:	25 May 2022 14:46
Last Modified:	17 Jan 2024 14:54
PMCID:	PMC9120417
URI:	https://repository.cshl.edu/id/eprint/40618

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