Transcriptional regulation of primary and specialized metabolism

Brady, Siobhan (May 2022) Transcriptional regulation of primary and specialized metabolism. The FASEB Journal, 36 (S1). ISSN 0892-6638

DOI: 10.1096/fasebj.2022.36.s1.0i148


Regulation of plant development requires intricate communication with both primary and specialized metabolism in order to fuel growth. While transcriptional regulation of metabolism is evident from myriad whole genome-expression analyses, our understanding of which transcriptional regulators are responsible for these changes as well as their underlying mode of action is unclear. I will highlight our efforts on systematic mapping of transcriptional regulators of primary metabolism (nitrogen and central carbon) as well as specialized metabolism (glucosinolates). Network analyses incorporating protein-DNA interaction data, gene expression and connectivity were used to identify critical regulators, most of which were shown to regulate metabolism via developmental- and stress-conditional processes that coordinate across primary and specialized metabolism. These analyses demonstrate distinct design principles responsible for metabolism between microbes and this multicellular eukaryote.

Item Type: Paper
CSHL Authors:
Communities: CSHL labs > Ware lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 13 May 2022
Date Deposited: 18 May 2022 14:04
Last Modified: 22 Nov 2023 19:18

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