Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Frangeul, Laura, Kehayas, Vassilis, Sanchez-Mut, Jose V, Fièvre, Sabine, Krishna-K, K, Pouchelon, Gabrielle, Telley, Ludovic, Bellone, Camilla, Holtmaat, Anthony, Gräff, Johannes, Macklis, Jeffrey D, Jabaudon, Denis (December 2017) Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons. Nature Communications, 8 (1). p. 2015. ISSN 2041-1723

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Abstract

Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. Here, using genetic and surgical manipulations of sensory input in mouse somatosensory thalamocortical neurons, we show that membrane excitability is a critical component of dendritic development. Using a combination of genetic approaches, we find that ablation of N-methyl-D-aspartate (NMDA) receptors during postnatal development leads to epigenetic repression of Kv1.1-type potassium channels, increased excitability, and impaired dendritic maturation. Lesions to whisker input pathways had similar effects. Overexpression of Kv1.1 was sufficient to enable dendritic maturation in the absence of sensory input. Thus, Kv1.1 acts to tune neuronal excitability and maintain it within a physiological range, allowing dendritic maturation to proceed. Together, these results reveal an input-dependent control over neuronal excitability and dendritic complexity in the development and plasticity of sensory pathways.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor neurobiology > neuroscience > dendritic maturation organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > thalamocortical neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > thalamocortical neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > thalamocortical neurons
CSHL Authors:	Pouchelon, Gabrielle
Communities:	CSHL labs > Pouchelon lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	8 December 2017
Date Deposited:	20 Dec 2021 14:31
Last Modified:	20 Dec 2021 14:31
PMCID:	PMC5722950
URI:	https://repository.cshl.edu/id/eprint/40462

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