Innate Immunity and Cancer Pathophysiology

Maiorino, Laura, Daßler-Plenker, Juliane, Sun, Lijuan, Egeblad, Mikala (November 2021) Innate Immunity and Cancer Pathophysiology. Annual Review of Pathology: Mechanisms of Disease, 17 (1). ISSN 1553-4006

DOI: 10.1146/annurev-pathmechdis-032221-115501


Chronic inflammation increases the risk of several cancers, including gastric, colon, and hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory response coordinated by the innate immune system. Cellular and molecular mediators of inflammation modulate tumor growth directly and by influencing the adaptive immune response. Depending on the balance of immune cell types and signals within the tumor microenvironment, inflammation can support or restrain the tumor. Adding to the complexity, research from the past two decades has revealed that innate immune cells are highly heterogeneous and plastic, with variable phenotypes depending on tumor type, stage, and treatment. The field is now on the cusp of being able to harness this wealth of data to (a) classify tumors on the basis of their immune makeup, with implications for prognosis, treatment choice, and clinical outcome, and (b) design therapeutic strategies that activate antitumor immune responses by targeting innate immune cells. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 17 is January 2022. Please see for revised estimates.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
diseases & disorders > neoplasms
diseases & disorders > cancer > drugs and therapies
diseases & disorders > inflammation
diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:
Communities: CSHL labs > Egeblad lab
School of Biological Sciences > Publications
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 17 November 2021
Date Deposited: 06 Dec 2021 15:40
Last Modified: 25 Jan 2024 15:16
PMCID: PMC9012188

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