The diversity and specificity of functional connectivity across spatial and temporal scales

Engel, Tatiana A, Schölvinck, Marieke L, Lewis, Christopher M (October 2021) The diversity and specificity of functional connectivity across spatial and temporal scales. NeuroImage, 245. p. 118692. ISSN 1053-8119

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DOI: 10.1016/j.neuroimage.2021.118692


Macroscopic neuroimaging modalities in humans have revealed the organization of brain-wide activity into distributed functional networks that re-organize according to behavioral demands. However, the inherent coarse-graining of macroscopic measurements conceals the diversity and specificity in responses and connectivity of many individual neurons contained in each local region. New invasive approaches in animals enable recording and manipulating neural activity at meso- and microscale resolution, with cell-type specificity and temporal precision down to milliseconds. Determining how brain-wide activity patterns emerge from interactions across spatial and temporal scales will allow us to identify the key circuit mechanisms contributing to global brain states and how the dynamic activity of these states enables adaptive behavior.

Item Type: Paper
Subjects: neurobiology > neuroanatomy
neurobiology > neuroscience
CSHL Authors:
Communities: CSHL labs > Engel lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 29 October 2021
Date Deposited: 10 Nov 2021 16:46
Last Modified: 23 Jan 2024 19:59
PMCID: PMC9531047

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