The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

Copin, Richard, Baum, Alina, Wloga, Elzbieta, Pascal, Kristen E, Giordano, Stephanie, Fulton, Benjamin O, Zhou, Anbo, Negron, Nicole, Lanza, Kathryn, Chan, Newton, Coppola, Angel, Chiu, Joyce, Ni, Min, Wei, Yi, Atwal, Gurinder S, Hernandez, Annabel Romero, Saotome, Kei, Zhou, Yi, Franklin, Matthew C, Hooper, Andrea T, McCarthy, Shane, Hamon, Sara, Hamilton, Jennifer D, Staples, Hilary M, Alfson, Kendra, Carrion, Ricardo, Ali, Shazia, Norton, Thomas, Somersan-Karakaya, Selin, Sivapalasingam, Sumathi, Herman, Gary A, Weinreich, David M, Lipsich, Leah, Stahl, Neil, Murphy, Andrew J, Yancopoulos, George D, Kyratsous, Christos A (June 2021) The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies. Cell. ISSN 0092-8674

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Abstract

Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we investigated the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-COV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or single monoclonal antibody treatments. Our study demonstrates that the combination of non-competing antibodies in REGEN-COV provides protection against all current SARS-CoV-2 variants of concern/interest and also protects against emergence of new variants and their potential seeding into the population in a clinical setting.

Item Type:	Paper
Subjects:	bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics diseases & disorders > viral diseases diseases & disorders > viral diseases > coronavirus > therapies and treatments > antibody therapy diseases & disorders > viral diseases > coronavirus diseases & disorders > viral diseases > coronavirus > covid 19 organs, tissues, organelles, cell types and functions > organs types and functions > lung bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > monoclonal antibody bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Atwal, Gurinder Singh
Communities:	CSHL labs > Atwal lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	5 June 2021
Date Deposited:	21 Jul 2021 13:43
Last Modified:	23 Jan 2024 19:26
PMCID:	PMC8179113
URI:	https://repository.cshl.edu/id/eprint/40297

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