Global copy number profiling of cancer genomes

Wang, X., Chen, M., Yu, X., Pornputtapong, N., Chen, H., Zhang, N., Powers, S., Krauthammer, M. (March 2016) Global copy number profiling of cancer genomes. Bioinformatics, 32 (6). pp. 926-928. ISSN 1367-4803

DOI: 10.1093/bioinformatics/btv676


In this article, we introduce a robust and efficient strategy for deriving global and allele-specific copy number alternations (CNA) from cancer whole exome sequencing data based on Log R ratios and B-allele frequencies. Applying the approach to the analysis of over 200 skin cancer samples, we demonstrate its utility for discovering distinct CNA events and for deriving ancillary information such as tumor purity.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
CSHL Authors:
Communities: CSHL Cancer Center Program > Cancer Genetics and Genomics Program
CSHL labs > Powers lab
Depositing User: Sasha Luks-Morgan
Date: 15 March 2016
Date Deposited: 16 Jun 2021 17:05
Last Modified: 16 Jun 2021 17:05
PMCID: PMC4907391
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