Baum, Alina, Ajithdoss, Dharani, Copin, Richard, Zhou, Anbo, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Mohammadi, Kusha, Musser, Bret, Atwal, Gurinder S, Oyejide, Adelekan, Goez-Gazi, Yenny, Dutton, John, Clemmons, Elizabeth, Staples, Hilary M, Bartley, Carmen, Klaffke, Benjamin, Alfson, Kendra, Gazi, Michal, Gonzalez, Olga, Dick, Edward, Carrion, Ricardo, Pessaint, Laurent, Porto, Maciel, Cook, Anthony, Brown, Renita, Ali, Vaneesha, Greenhouse, Jack, Taylor, Tammy, Andersen, Hanne, Lewis, Mark G, Stahl, Neil, Murphy, Andrew J, Yancopoulos, George D, Kyratsous, Christos A (November 2020) REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters. Science, 370 (6520). pp. 1110-1115. ISSN 0036-8075
Abstract
An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in the lower and upper airways and decrease virus-induced pathological sequelae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders diseases & disorders > viral diseases organism description > animal bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > antibodies diseases & disorders > viral diseases > coronavirus > therapies and treatments > antibody therapy diseases & disorders > viral diseases > coronavirus diseases & disorders > viral diseases > coronavirus > covid 19 organism description > animal > mammal organism description > animal > mammal > primates > monkey organism description > animal > mammal > primates |
| CSHL Authors: | |
| Communities: | CSHL labs > Atwal lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 27 November 2020 |
| Date Deposited: | 29 Apr 2021 19:59 |
| Last Modified: | 29 Jan 2024 20:13 |
| PMCID: | PMC7857396 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39956 |
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