Social isolation uncovers a circuit underlying context-dependent territory-covering micturition.

Hyun, Minsuk, Taranda, Julian, Radeljic, Gianna, Miner, Lauren, Wang, Wengang, Ochandarena, Nicole, Huang, Kee Wui, Osten, Pavel, Sabatini, Bernardo L (January 2021) Social isolation uncovers a circuit underlying context-dependent territory-covering micturition. Proceedings of the National Academy of Sciences of USA, 118 (1). e2018078118-e2018078118. ISSN 0027-8424

URL: https://www.ncbi.nlm.nih.gov/pubmed/33443190
DOI: 10.1073/pnas.2018078118

Abstract

The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal cord via the pontine micturition center (PMC). Here, we exploited a behavioral paradigm in which mice, depending on strain, social experience, and sensory context, either vigorously cover an arena with small urine spots or deposit urine in a few isolated large spots. We refer to these micturition modes as, respectively, high and low territory-covering micturition (TCM) and find that the presence of a urine stimulus robustly induces high TCM in socially isolated mice. Comparison of the brain networks activated by social isolation and by urine stimuli to those upstream of the PMC identified the lateral hypothalamic area as a potential modulator of micturition modes. Indeed, chemogenetic manipulations of the lateral hypothalamus can switch micturition behavior between high and low TCM, overriding the influence of social experience and sensory context. Our results suggest that both inhibitory and excitatory signals arising from a network upstream of the PMC are integrated to determine context- and social-experience-dependent micturition patterns.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > brainstem
organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus
organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus
organism description > animal behavior > micturition
CSHL Authors:
Communities: CSHL labs > Osten lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 5 January 2021
Date Deposited: 29 Apr 2021 18:39
Last Modified: 29 Apr 2021 18:39
PMCID: PMC7817200
Related URLs:
URI: https://repository.cshl.edu/id/eprint/39951

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