Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism.

Cheadle, Lucas, Rivera, Samuel A, Phelps, Jasper S, Ennis, Katelin A, Stevens, Beth, Burkly, Linda C, Lee, Wei-Chung Allen, Greenberg, Michael E (November 2020) Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism. Neuron, 108 (3). 451-468.e9. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/32931754

DOI: 10.1016/j.neuron.2020.08.002

Abstract

Sensory experience remodels neural circuits in the early postnatal brain through mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis to the retinogeniculate circuit, we find that visual experience alters the number and structure of synapses between the retina and the thalamus. These changes require vision-dependent transcription of the receptor Fn14 in thalamic relay neurons and the induction of its ligand TWEAK in microglia. Fn14 functions to increase the number of bulbous spine-associated synapses at retinogeniculate connections, likely contributing to the strengthening of the circuit that occurs in response to visual experience. However, at retinogeniculate connections near TWEAK-expressing microglia, TWEAK signals via Fn14 to restrict the number of bulbous spines on relay neurons, leading to the elimination of a subset of connections. Thus, TWEAK and Fn14 represent an intercellular signaling axis through which microglia shape retinogeniculate connectivity in response to sensory experience.

Item Type:	Paper
Subjects:	Investigative techniques and equipment organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions Investigative techniques and equipment > microscopy > electron microscopy organism description > animal > mammal organs, tissues, organelles, cell types and functions > cell types and functions > cell types > microglia organs, tissues, organelles, cell types and functions > cell types and functions > cell types > microglia organs, tissues, organelles, cell types and functions > cell types and functions > cell types > microglia Investigative techniques and equipment > microscopy organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:	Cheadle, Lucas
Communities:	CSHL labs > Cheadle lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	11 November 2020
Date Deposited:	19 Feb 2021 21:01
Last Modified:	29 Jan 2024 20:43
PMCID:	PMC7666095
URI:	https://repository.cshl.edu/id/eprint/39909

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