New Approaches to SCLC Therapy: From the Laboratory to the Clinic

Poirier, J. T., George, J., Owonikoko, T. K., Berns, A., Brambilla, E., Byers, L. A., Carbone, D., Chen, H. J., Christensen, C. L., Dive, C., Farago, A. F., Govindan, R., Hann, C., Hellmann, M. D., Horn, L., Johnson, J. E., Ju, Y. S., Kang, S., Krasnow, M., Lee, J., Lee, S. H., Lehman, J., Lok, B., Lovly, C., MacPherson, D., McFadden, D., Minna, J., Oser, M., Park, K., Park, K. S., Pommier, Y., Quaranta, V., Ready, N., Sage, J., Scagliotti, G., Sos, M. L., Sutherland, K. D., Travis, W. D., Vakoc, C. R., Wait, S. J., Wistuba, I., Wong, K. K., Zhang, H., Daigneault, J., Wiens, J., Rudin, C. M., Oliver, T. G. (April 2020) New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J Thorac Oncol, 15 (4). pp. 520-540. ISSN 1556-0864 (Print)1556-0864

DOI: 10.1016/j.jtho.2020.01.016


The outcomes of patients with SCLC have not yet been substantially impacted by the revolution in precision oncology, primarily owing to a paucity of genetic alterations in actionable driver oncogenes. Nevertheless, systemic therapies that include immunotherapy are beginning to show promise in the clinic. Although, these results are encouraging, many patients do not respond to, or rapidly recur after, current regimens, necessitating alternative or complementary therapeutic strategies. In this review, we discuss ongoing investigations into the pathobiology of this recalcitrant cancer and the therapeutic vulnerabilities that are exposed by the disease state. Included within this discussion, is a snapshot of the current biomarker and clinical trial landscapes for SCLC. Finally, we identify key knowledge gaps that should be addressed to advance the field in pursuit of reduced SCLC mortality. This review largely summarizes work presented at the Third Biennial International Association for the Study of Lung Cancer SCLC Meeting.

Item Type: Paper
Additional Information: 1556-1380 Poirier, John T George, Julie Owonikoko, Taofeek K Berns, Anton Brambilla, Elisabeth Byers, Lauren A Carbone, David Chen, Huanhuan J Christensen, Camilla L Dive, Caroline Farago, Anna F Govindan, Ramaswamy Hann, Christine Hellmann, Matthew D Horn, Leora Johnson, Jane E Ju, Young S Kang, Sumin Krasnow, Mark Lee, James Lee, Se-Hoon Lehman, Jonathan Lok, Benjamin Lovly, Christine MacPherson, David McFadden, David Minna, John Oser, Matthew Park, Keunchil Park, Kwon-Sik Pommier, Yves Quaranta, Vito Ready, Neal Sage, Julien Scagliotti, Giorgio Sos, Martin L Sutherland, Kate D Travis, William D Vakoc, Christopher R Wait, Sarah J Wistuba, Ignacio Wong, Kwok Kin Zhang, Hua Daigneault, Jillian Wiens, Jacinta Rudin, Charles M Oliver, Trudy G U01 CA213273/CA/NCI NIH HHS/United States U01 CA231851/CA/NCI NIH HHS/United States U01 CA213359/CA/NCI NIH HHS/United States R21 CA216504/CA/NCI NIH HHS/United States U01 CA231844/CA/NCI NIH HHS/United States P30 CA008748/CA/NCI NIH HHS/United States R35 CA231997/CA/NCI NIH HHS/United States U01 CA242919/CA/NCI NIH HHS/United States R01 CA207295/CA/NCI NIH HHS/United States R01 CA213448/CA/NCI NIH HHS/United States K99 CA201618/CA/NCI NIH HHS/United States U54 CA217450/CA/NCI NIH HHS/United States U01 CA213338/CA/NCI NIH HHS/United States R01 CA181449/CA/NCI NIH HHS/United States U24 CA213274/CA/NCI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review J Thorac Oncol. 2020 Apr;15(4):520-540. doi: 10.1016/j.jtho.2020.01.016. Epub 2020 Feb 1.
Uncontrolled Keywords: *ascl1 *Gene mutations *Neuroendocrine *sclc *Therapy
Subjects: diseases & disorders > cancer
diseases & disorders
diseases & disorders > neoplasms
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > drugs and therapies > precision medicine
Publication Type > review
diseases & disorders > cancer > cancer types > small cell lung cancer
CSHL Authors:
Communities: CSHL labs > Vakoc lab
Depositing User: Matthew Dunn
Date: April 2020
Date Deposited: 14 Dec 2020 17:52
Last Modified: 01 Feb 2024 16:51
PMCID: PMC7263769
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