Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

Gallo, N. B., Paul, A., Van Aelst, L. (June 2020) Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders. Trends in Neurosciences, 43 (8). pp. 565-580. ISSN 0166-2236

Abstract

Chandelier cells (ChCs) are a unique type of GABAergic interneuron that selectively innervate the axon initial segment (AIS) of excitatory pyramidal neurons; the subcellular domain where action potentials are initiated. The proper genesis and maturation of ChCs is critical for regulating neural ensemble firing in the neocortex throughout development and adulthood. Recently, genetic and molecular studies have shed new light on the complex innerworkings of ChCs in health and disease. This review presents an overview of recent studies on the developmental origins, migratory properties, and morphology of ChCs. In addition, attention is given to newly identified molecules regulating ChC morphogenesis and connectivity as well as recent work linking ChC dysfunction to neural disorders, including schizophrenia, epilepsy, and autism spectrum disorder (ASD).

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > personality disorders diseases & disorders > mental disorders > personality disorders > autism organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > tissues types and functions > neocortex organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Van Aelst, Linda Gallo, Nicholas Paul, Anirban
Communities:	CSHL labs > Van Aelst lab
Depositing User:	Matthew Dunn
Date:	June 2020
Date Deposited:	06 Jul 2020 16:46
Last Modified:	29 Jan 2024 21:19
PMCID:	PMC7392791
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/39503

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