Borniger, J. C. (2019) Central regulation of breast cancer growth and metastasis. J Cancer Metastasis Treat, 5. ISSN 2394-4722
Abstract
Cancer is a systemic disease. In order to fully understand it, we must take a holistic view on how cancer interacts with its host. The brain monitors and responds to natural and aberrant signals arriving from the periphery, particularly those of metabolic or immune origin. As has been well described, a hallmark of cancer is marked disruption of metabolic and inflammatory processes. Depending on the salience and timing of these inputs, the brain responds via neural and humoral routes to alter whole-body physiology. These responses have consequences for tumor growth and metastasis, directly influencing patient quality of life and subsequent mortality. Additionally, environmental inputs such as light, diet, and stress, can promote inappropriate neural activity that benefits cancer. Here, I discuss evidence for brain-tumor interactions, with special emphasis on subcortical neuromodulator neural populations, and potential ways of harnessing this cross-talk as a novel approach for cancer treatment.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > cancer types > breast cancer organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus organs, tissues, organelles, cell types and functions > organs types and functions > metabolism diseases & disorders > cancer > metastasis organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL labs > Borniger lab |
| Depositing User: | Adrian Gomez |
| Date: | 2019 |
| Date Deposited: | 03 Jan 2020 19:04 |
| Last Modified: | 01 Feb 2024 20:40 |
| PMCID: | PMC6879058 |
| URI: | https://repository.cshl.edu/id/eprint/38841 |
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