Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences

Baker, A., Kalmbach, B., Morishima, M., Kim, J., Juavinett, A., Li, N., Dembrow, N. (May 2018) Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences. J Neurosci, 38 (24). pp. 5441-5455. ISSN 0270-6474

URL: https://www.ncbi.nlm.nih.gov/pubmed/29798890

DOI: 10.1523/jneurosci.0150-18.2018

Abstract

Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) integrate a plethora of cortical and extracortical synaptic inputs along their impressive dendritic arbors. The pattern of cortical output to both local and long-distance targets is sculpted by the unique physiological properties of specific DLPN subpopulations. Here we revisit two broad DLPN subpopulations: those that send their axons within the telencephalon (intratelencephalic, or IT neurons) and those that project to additional target areas outside the telencephalon (extratelencephalic, or ET neurons). While neuroscientists across many subdisciplines have characterized the intrinsic and synaptic physiological properties of DLPN subpopulations, our increasing ability to selectively target and manipulate these output neuron subtypes advances our understanding of their distinct functional contributions. This Viewpoints article summarizes our current knowledge about DLPNs, and highlights recent work elucidating the functional differences between DLPN subpopulations.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > neocortex organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Juavinett, Ashley
Communities:	CSHL labs > Churchland lab
Depositing User:	Matt Covey
Date:	21 May 2018
Date Deposited:	01 Jun 2018 19:59
Last Modified:	06 Feb 2024 21:00
PMCID:	PMC6001033
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/36708

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