Sedlazeck, F. J., Lee, H., Darby, C. A., Schatz, M. C. (June 2018) Piercing the dark matter: bioinformatics of long-range sequencing and mapping. Nat Rev Genet, 19 (6). pp. 329-346. ISSN 1471-0056
Abstract
Several new genomics technologies have become available that offer long-read sequencing or long-range mapping with higher throughput and higher resolution analysis than ever before. These long-range technologies are rapidly advancing the field with improved reference genomes, more comprehensive variant identification and more complete views of transcriptomes and epigenomes. However, they also require new bioinformatics approaches to take full advantage of their unique characteristics while overcoming their complex errors and modalities. Here, we discuss several of the most important applications of the new technologies, focusing on both the currently available bioinformatics tools and opportunities for future research.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > Mapping and Rendering Investigative techniques and equipment > assays > long-read sequencing Investigative techniques and equipment > assays > next generation sequencing |
| CSHL Authors: | |
| Communities: | CSHL labs > Schatz lab |
| Depositing User: | Matt Covey |
| Date: | June 2018 |
| Date Deposited: | 05 Apr 2018 20:12 |
| Last Modified: | 01 Jun 2018 19:54 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/36342 |
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