Greenberg, E., Tung, E. S., Gauvin, C., Osiecki, L., Yang, K. G., Curley, E., Essa, A., Illmann, C., Sandor, P., Dion, Y., Lyon, G. J., King, R. A., Darrow, S., Hirschtritt, M. E., Budman, C. L., Grados, M., Pauls, D. L., Keuthen, N. J., Mathews, C. A., Scharf, J. M. (May 2018) Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome. Eur Child Adolesc Psychiatry, 27 (5). pp. 569-579. ISSN 1018-8827
Abstract
Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study. Patients were assessed using standardized, validated semi-structured interviews. HPD and SPD diagnoses were determined using a validated self-report questionnaire. HPD/SPD prevalence rates were calculated, and clinical predictors were evaluated using regression modeling. 3.8 and 13.0% of TS patients met DSM-5 criteria for HPD and SPD, respectively. In univariable analyses, female sex, OCD, and both tic and obsessive-compulsive symptom severity were among those associated with HPD and/or SPD. In multivariable analyses, only lifetime worst-ever motor tic severity remained significantly associated with HPD. Female sex, co-occurring OCD, ADHD, and motor tic severity remained independently associated with SPD. This is the first study to examine HPD and SPD prevalence in a TS sample using semi-structured diagnostic instruments. The prevalence of HPD and SPD in TS patients, and their association with increased tic severity and co-occurring OCD, suggests that clinicians should screen children with TS and related disorders for HPD/SPD, particularly in females and in those with co-occurring OCD. This study also helps set a foundation for subsequent research regarding HPD/SPD risk factors, pathophysiology, and treatment models.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Body-focused repetitive behaviors Excoriation disorder/skin picking disorder Obsessive-compulsive disorder Tourette syndrome Trichotillomania/hair pulling disorder |
| Subjects: | diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > Tourette Syndrome |
| CSHL Authors: | |
| Communities: | CSHL labs > Lyon lab |
| Depositing User: | Matt Covey |
| Date: | 2 May 2018 |
| Date Deposited: | 15 Nov 2017 20:12 |
| Last Modified: | 20 Feb 2024 20:03 |
| PMCID: | PMC5932289 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35663 |
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