Minota, S., Cameron, B., Welch, W. J., Winfield, J. B. (October 1988) Autoantibodies to the Constitutive 73-Kd Member of the Hsp70-Family of Heat-Shock Proteins in Systemic Lupus-Erythematosus. Journal of Experimental Medicine, 168 (4). pp. 1475-1480. ISSN 0022-1007
Abstract
Serum from patients with systemic lupus erythematosus (SLE) frequently contain IgM and IgG autoantibodies to the constitutively expressed 73-kD/pI 5.5 member of the hsp70 family of heat shock proteins, as determined by one-dimensional (SDS-PAGE) and two-dimensional (IEF/SDS-PAGE) immunoblotting, and by solid-phase SLE Ig immunoprecipitation experiments using hsp70 protein-specific mAbs as probes. Autoantibodies to hsp70 also were detected in a minority of sera from patients with other rheumatic or viral diseases, but not in normal sera. These data may provide additional insight into etiologic and pathophysiologic mechanisms in this and related autoimmune disorders.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > immune system diseases > auto immune diseases bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > antibodies bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | October 1988 |
| Date Deposited: | 26 Sep 2017 19:50 |
| Last Modified: | 26 Sep 2017 19:50 |
| PMCID: | PMC2189089 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35182 |
Actions (login required)
 |
Administrator's edit/view item |