Intracellular mediators of c-fos induction

Gilman, M. Z., Berkowitz, L. A., Feramisco, J. R., Franza, B. R., Graham, R. M., Riabowol, K. T., Ryan, W. A. (1988) Intracellular mediators of c-fos induction. Cold Spring Harb Symp Quant Biol, 53 Pt . pp. 761-7. ISSN 0091-7451



Transcription of the c-fos proto-oncogene is rapidly and transiently induced in cells exposed to a remarkably wide range of external stimuli, including growth and differentiation factors, neurotransmitters, drugs, and mechanical stimuli (for review, see Curran 1988). These diverse agents act on cells through a series of divergent signal transduction pathways. Activation of many of these pathways triggers c-fos transcription. These pathways include those involving protein kinase C, calcium, and cAMP. Our work concerns the molecular mechanisms through which extracellular signals are communicated to the c-fos gene. Here, we report on our efforts to identify cis-acting c-fos sequences responsive to distinct intracellular signaling pathways, the identification of cellular DNA-binding proteins that interact with these sequences, and the use of microinjection to dissect and block individual signaling pathways that act on the c-fos gene.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence Cell Line Cell Nucleus/physiology Cells, Cultured DNA-Binding Proteins/*genetics Mice Mice, Inbred BALB C Molecular Sequence Data Mutation Plasmids Proto-Oncogene Proteins/biosynthesis/*genetics Proto-Oncogene Proteins c-fos *Proto-Oncogenes Rats Regulatory Sequences, Nucleic Acid Research Support, U.S. Gov't, P.H.S. *Signal Transduction Transfection
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > c-fos
organism description > animal > mammal > rodent
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: 1988
Date Deposited: 12 Oct 2017 18:02
Last Modified: 12 Oct 2017 18:02
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