Beyond the 2nd Messenger - Oncogenes and Transcription Factors

Curran, T., Rauscher, F. J., Cohen, D. R., Franza, B. R. (May 1988) Beyond the 2nd Messenger - Oncogenes and Transcription Factors. Cold Spring Harbor Symposia on Quantitative Biology, 53. pp. 769-777. ISSN 0091-7451

DOI: 10.1101/SQB.1988.053.01.087


Neoplasia is the consequence of a breakdown in the mechanisms responsible for the regulation of cell growth and development. The cancer cell either fails to respond or responds inappropriately to environmental cues. The last decade of research on retroviral oncogenes (v-onc) and their cellular progenitors, proto-oncogenes (c-onc), has yielded specific nucleic acid and antibody probes that are now being used to dissect the causes and consequences of this failure of inter- and intracellular communication. A unifying theme arising from these investigations is that oncogene products appear to function in the transmission of information between and within cells, i.e. in signal transduction processes. Several proto-oncogenes have now been shown to encode proteins similar or identical to growth factors and their receptors, G proteins, protein kinases, or nuclear proteins induced by growth factors (for review, see Heldin and Westermark 1984; Bishop 1985; Curran et al. 1985; Gilman 1987).

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: 25 May 1988
Date Deposited: 18 Oct 2017 19:01
Last Modified: 18 Oct 2017 19:01
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