lncRNAs in development and disease: from functions to mechanisms

Delas, M. J., Hannon, G. J. (July 2017) lncRNAs in development and disease: from functions to mechanisms. Open Biol, 7 (7). ISSN 2046-2441

URL: https://www.ncbi.nlm.nih.gov/pubmed/28747406
DOI: 10.1098/rsob.170121


Differential expression of long non-coding RNAs (lncRNAs) during differentiation and their misregulation in cancer highlight their potential as cell fate regulators. While some example lncRNAs have been characterized in great detail, the functional in vivo relevance of others has been called into question. Finding functional lncRNAs will most probably require a combination of complementary approaches that will greatly vary depending on their mode of action. In this review, we discuss the different tools available to dissect genetically lncRNA requirements and how each is best suited to studies in particular contexts. Moreover, we review different strategies used to select candidate lncRNAs and give an overview of lncRNAs described to regulate development and cancer through different mechanisms.

Item Type: Paper
Uncontrolled Keywords: cancer development long non-coding RNAs
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA
CSHL Authors:
Communities: CSHL labs > Hannon lab
School of Biological Sciences > Publications
Depositing User: Matt Covey
Date: July 2017
Date Deposited: 31 Jul 2017 19:45
Last Modified: 21 Aug 2017 14:45
PMCID: PMC5541349
Related URLs:
URI: https://repository.cshl.edu/id/eprint/35078

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