Sarvetnick, N., Tsai, J. Y., Fox, H., Pilder, S. H., Silver, L. M. (July 1989) A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. Immunogenetics, 30 (1). pp. 34-41. ISSN 0093-7711
Abstract
We have characterized a novel mouse gene (D17Si11) on chromosome 17 that expresses a major transcript observed uniquely in the testes. The D17Si11 locus has been mapped to the central region of chromosome 17 between H-2 and C3. Sequence analysis demonstrates several unusual features of this locus and its transcript: first is the presence of complementary sets of alternating purine and pyrimidine residues within the 3' region of the transcript that could form double-stranded, hairpin-like secondary structures with properties similar to that of Z-DNA; second is the existence of a hypothetical, long open reading frame in the nucleotide strand that is complementary to the testes transcripts. This complementary strand open reading frame is three times the size of the longest potential open reading frame present in the transcript itself. Although a function for D17Si11 has yet to be determined, the gene is relatively nonpolymorphic in mice and appears conserved in mammals.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Animals Base Sequence Cell Differentiation *Chromosome Mapping Cloning, Molecular DNA/*analysis Male Mice/*genetics Molecular Sequence Data Polymorphism, Restriction Fragment Length Proteins/genetics Research Support, U.S. Gov't, P.H.S. Sequence Homology, Nucleic Acid Spermatozoa/*physiology Testis/cytology/physiology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome organism description > animal > mammal > rodent > mouse |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | July 1989 |
| Date Deposited: | 23 Jun 2017 18:42 |
| Last Modified: | 23 Jun 2017 18:42 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34904 |
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