Organization and expression of 5S rRNA genes in the parasitic nematode,Brugia malayi

Ransohoff, R. M., Denker, J. A., Takacs, A. M., Hannon, G. J., Nilsen, T. W. (May 1989) Organization and expression of 5S rRNA genes in the parasitic nematode,Brugia malayi. Nucleic Acids Research, 17 (10). pp. 3773-3782. ISSN 03051048

DOI: 10.1093/nar/17.10.3773


DNA sequence analysis of genes encoding 5S rRNA in the human parasitic nematode Brugia malayi (B. malayi) indicates a surprising degree of heterogeneity. This variation in coding sequence is not accompanied by corresponding heterogeneity in flanking regions which are highly conserved. Six out of eight potential 5S coding regions differed; of these sequence variants, two were abundant in the B. malayi genome. Direct RNA sequence analysis indicated that one of these abundant variants accounts for most if not all of expressed 5S RNA at two stages of development.

Item Type: Paper
Uncontrolled Keywords: ribosome rna brugia malayi dna sequence filaria gene expression nematode nonhuman parasite development rna gene Animal Base Sequence Blotting, Southern Brugia Chromosome Deletion Cloning, Molecular DNA Genes Molecular Sequence Data RNA, Ribosomal RNA, Ribosomal, 5S Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Variation (Genetics)
Subjects: bioinformatics > genomics and proteomics > analysis and processing > DNA RNA Processing
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: Gail Sherman
Date: 25 May 1989
Date Deposited: 26 Jun 2017 19:45
Last Modified: 26 Jun 2017 19:45
PMCID: PMC317858
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