McDonald, J. W., Cline, H. T., Constantine-Paton, M., Maragos, W. F., Johnston, M. V., Young, A. B. (March 1989) Quantitative autoradiographic localization of NMDA, quisqualate and PCP receptors in the frog tectum. Brain Res, 482 (1). pp. 155-8. ISSN 1872-6240
Abstract
An organizing role for the N-methyl-D-aspartate (NMDA) receptor/channel has been suggested in the development of the retinotectal projection in Rana pipiens. The regional distributions of NMDA, phencyclidine (PCP) and quisqualic acid (QA) receptors were quantified using in vitro autoradiography in the tectum of normal and surgically produced 3-eyed juvenile frogs. NMDA and QA receptor binding was highest in the pretectum. Of the tectal layers, the superficial retinotectal synaptic zone, layer 9, had the highest amount of NMDA and QA receptor binding. Moderate binding was observed in layer 5, with little binding in the cellular layer 6. No specific [3H]N-(1-[2-thienyl]cyclohexyl) piperidine ([3H]TCP) binding was observed in any of the tectal regions.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Autoradiography Rana pipiens/*metabolism Receptors, AMPA Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/*metabolism Receptors, Phencyclidine Superior Colliculus/*metabolism |
| Subjects: | organism description > animal > Frog bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor |
| CSHL Authors: | |
| Communities: | CSHL labs > Cline lab |
| Depositing User: | Gail Sherman |
| Date: | 13 March 1989 |
| Date Deposited: | 27 Jun 2017 16:33 |
| Last Modified: | 27 Jun 2017 16:33 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34877 |
Actions (login required)
 |
Administrator's edit/view item |