Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes

Lambert, M. E., Ronai, Z. A., Weinstein, I. B., Garrels, J. I. (February 1989) Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes. Molecular & Cellular Biology, 9 (2). pp. 847-50. ISSN 1098-5549

URL: http://www.ncbi.nlm.nih.gov/pubmed/2469006http://m...
DOI: 10.1128/MCB.9.2.847

Abstract

Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.

Item Type: Paper
Uncontrolled Keywords: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/pharmacology Cells, Cultured Cycloheximide/pharmacology *DNA Damage Epidermis/drug effects/immunology/radiation effects Fibroblasts/drug effects/immunology/radiation effects *Histocompatibility Antigens Class I Humans Keratin/metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Ultraviolet Rays
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organism description > animal > mammal > primates > hominids > human
organism description > virus > papovavirus
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: February 1989
Date Deposited: 28 Jun 2017 19:54
Last Modified: 28 Jun 2017 19:54
PMCID: PMC362666
Related URLs:
URI: https://repository.cshl.edu/id/eprint/34869

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