Lambert, M. E., Ronai, Z. A., Weinstein, I. B., Garrels, J. I. (February 1989) Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes. Molecular & Cellular Biology, 9 (2). pp. 847-50. ISSN 1098-5549
Abstract
Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/pharmacology Cells, Cultured Cycloheximide/pharmacology *DNA Damage Epidermis/drug effects/immunology/radiation effects Fibroblasts/drug effects/immunology/radiation effects *Histocompatibility Antigens Class I Humans Keratin/metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Ultraviolet Rays |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organism description > animal > mammal > primates > hominids > human organism description > virus > papovavirus |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | February 1989 |
| Date Deposited: | 28 Jun 2017 19:54 |
| Last Modified: | 28 Jun 2017 19:54 |
| PMCID: | PMC362666 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34869 |
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