Tai, Y., Jia, Y. (May 2017) TRPC Channels and Neuron Development, Plasticity, and Activities. Adv Exp Med Biol, 976. pp. 95-110. ISSN 0065-2598 (Print)0065-2598
Abstract
In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their functions in sensation and nociception in dorsal root ganglion (DRG). Because TRPC channels are expressed in all major types of glial cells, which account for at least half of total cells in the brain, TRPC channels may act as modulators for glial functions as well. The future challenges for studying these channels could be (1) the detailed protein structures of these channels, (2) their cell type-specific functions, (3) requirement for their specific blockers or activators, and (4) change in the channel conformation in the brain.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Development Neuron Plasticity TRPC channels |
| Subjects: | organs, tissues, organelles, cell types and functions > organs types and functions > brain organism description > animal > developmental stage organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity |
| CSHL Authors: | |
| Communities: | CSHL labs > Van Aelst lab |
| Depositing User: | Matt Covey |
| Date: | May 2017 |
| Date Deposited: | 19 May 2017 20:10 |
| Last Modified: | 19 May 2017 20:10 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34793 |
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