Garbay, D., Maki, R. G., Blay, J. Y., Isambert, N., Piperno Neumann, S., Blay, C., Zanardi, E., Boudou-Rouquette, P., Bozec, L., Duffaud, F., Bertucci, F., Italiano, A. (July 2013) Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival. Ann Oncol, 24 (7). pp. 1924-30. ISSN 1569-8041 (Electronic)0923-7534 (Linking)
Abstract
BACKGROUND: There are no data regarding the management of advanced soft-tissue sarcoma (STS) in elderly patients. PATIENTS AND METHODS: We retrospectively reviewed the charts of patients >/=75 years old diagnosed with metastatic or unresectable STS between 1991 and 2011 in 11 French and American centers. RESULTS: The study included 361 patients. Of these, 223 patients (62%) received systemic therapy, whereas 123 patients (34%) were managed with best supportive care (BSC) only. Patients who received BSC were more likely to be >/=80 years, with performance status (PS) >/= 2, Charlson comorbidity score >/= 10, and metastatic disease. The median progression-free survival of patients treated with systemic therapy was 4 months (95% CI: 2.9-5.1). Thirty-six patients (16%) stopped chemotherapy because of toxicity. Median overall survival (OS) of patients managed with specific therapy was 10.9 months (95% CI: 8.3-13.5) versus 5.3 months (95% CI: 3.6-7.1) for patients managed with BSC (P = 0.001). On multivariate analysis, age >/= 80 years, PS >/= 2, and number of metastatic sites were the only independent factors associated with OS. CONCLUSION: A high proportion of elderly patients with advanced STS were denied chemotherapy. Further efforts are needed to define better the optimal care for fit and unfit elderly patients with STS.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Aged Aged, 80 and over Anthracyclines/*therapeutic use Antineoplastic Agents/*therapeutic use Disease-Free Survival Female Humans Kaplan-Meier Estimate Male Palliative Care Retrospective Studies Sarcoma/*drug therapy/mortality/secondary Soft Tissue Neoplasms/*drug therapy/mortality/pathology Treatment Outcome chemotherapy elderly sarcoma soft-tissue sarcoma |
| Subjects: | diseases & disorders > cancer > prognosis diseases & disorders > cancer > cancer types > sarcoma |
| CSHL Authors: | |
| Communities: | CSHL labs > Maki lab |
| Depositing User: | Matt Covey |
| Date: | July 2013 |
| Date Deposited: | 20 Oct 2016 16:39 |
| Last Modified: | 20 Oct 2016 16:39 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/33750 |
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