Elevations of creatine kinase in patients treated with imatinib mesylate (Gleevec)

Gordon, J. K., Magid, S. K., Maki, R. G., Fleisher, M., Berman, E. (June 2010) Elevations of creatine kinase in patients treated with imatinib mesylate (Gleevec). Leuk Res, 34 (6). pp. 827-9. ISSN 1873-5835 (Electronic)0145-2126 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/19963273
DOI: 10.1016/j.leukres.2009.11.002


Imatinib mesylate is used with increasing frequency and duration for the treatment of chronic myelogenous leukemia (CML), gastrointestinal stromal tumor (GIST), and other neoplastic conditions. Although muscular complaints are common, elevations of creatine kinase (CK) are listed as <1% in the product label. We describe here a case of rhabdomyolysis likely related to imatinib as well as the results of a prospective evaluation of CK levels in a cohort of patients on imatinib for CML or GIST. We found a high prevalence of CK abnormalities in this group and believe that CKs should be monitored during therapy with imatinib.

Item Type: Paper
Uncontrolled Keywords: Adult Aged Antineoplastic Agents/adverse effects/therapeutic use Benzamides Case-Control Studies Cohort Studies Creatine Kinase/*blood Edema/blood/chemically induced Female Gastrointestinal Stromal Tumors/blood/drug therapy Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*blood/drug therapy Male Middle Aged Muscular Diseases/blood/chemically induced Piperazines/adverse effects/*therapeutic use Pyrimidines/adverse effects/*therapeutic use Up-Regulation/drug effects Young Adult
Subjects: diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > gastrointestinal stromal tumors
diseases & disorders > cancer > cancer types > leukemia
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: June 2010
Date Deposited: 21 Oct 2016 19:51
Last Modified: 21 Oct 2016 19:51
Related URLs:
URI: https://repository.cshl.edu/id/eprint/33708

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