Evidence-based recommendations for local therapy for soft tissue sarcomas

Pisters, P. W., O'Sullivan, B., Maki, R. G. (March 2007) Evidence-based recommendations for local therapy for soft tissue sarcomas. J Clin Oncol, 25 (8). pp. 1003-8. ISSN 1527-7755 (Electronic)0732-183X (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/17350950
DOI: 10.1200/JCO.2006.09.8525


There has been a gradual migration in the local treatment of soft tissue sarcomas from amputation and similar radical resectional approaches to more conservative, function-preserving surgery combined with radiotherapy. This progress has been made possible by small, single-institution, randomized trials that demonstrated the superiority of this more conservative, combined-modality approach. In the new millennium, attention has shifted to defining subsets of patients who might be adequately treated by surgery alone and defining the optimal sequence of surgery and radiation for patients who require both types of local therapy. There remains considerable discussion and debate surrounding the issue of pre- and postoperative chemotherapy for patients with localized soft tissue sarcomas. Adjuvant chemotherapy is a standard of care for adults who have the subtypes of soft tissue sarcomas that typically occur in pediatric patients (Ewing sarcoma, rhabdomyosarcoma), and just as clearly, adjuvant chemotherapy is not warranted in patients with low- and intermediate-risk disease (stages I and II). For patients with higher risk disease (stage III), the available randomized trials do not convincingly demonstrate a clinical benefit to adjuvant chemotherapy. As such, a complete accounting of potential risks and benefits is appropriate when discussing adjuvant chemotherapy with patients who have stage III disease.

Item Type: Paper
Uncontrolled Keywords: Chemotherapy, Adjuvant Combined Modality Therapy Evidence-Based Medicine Humans Randomized Controlled Trials as Topic Sarcoma/*therapy
Subjects: diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > sarcoma
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 10 March 2007
Date Deposited: 26 Oct 2016 16:25
Last Modified: 26 Oct 2016 16:25
Related URLs:
URI: https://repository.cshl.edu/id/eprint/33679

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