Adenovirus-2 messengers--an example of baroque molecular architecture

Broker, T. R., Chow, L. T., Dunn, A. R., Gelinas, R. E., Hassell, J. A., Klessig, D. F., Lewis, J. B., Roberts, R. J., Zain, B. S. (1978) Adenovirus-2 messengers--an example of baroque molecular architecture. Cold Spring Harb Symp Quant Biol, 42 Pt . pp. 531-53. ISSN 0091-7451 (Print)0091-7451 (Linking)

DOI: 10.1101/SQB.1978.042.01.056


Adenovirus type 2 (Ad2) causes respiratory infections in humans, grows productively on human cell lines such as HeLa and KB, and can transform rat primary cell lines (Tooze 1973). The Ad2 virion consists of a linear duplex DNA chromosome 35,000 base pairs (bp) long (23 × 106 daltons) contained within an icosahedral capsid composed of at least ten different proteins. After penetration of the cell membrane, the viral DNA and several core proteins associated with it are transported to the nucleus, where early RNA transcription begins within 2 hours. About 8 hours after infection, viral DNA replication commences, reaching a maximum rate several hours later. Late transcription to produce messenger RNA (mRNA) for capsid and other virus-specific proteins begins after the onset of DNA replication and continues for about 2 days, when the infected cells die.

Item Type: Paper
Uncontrolled Keywords: Adenoviruses, Human/*genetics Base Sequence Chromosome Mapping Microscopy, Electron Nucleic Acid Precursors/*genetics RNA/genetics RNA, Messenger/*genetics
Subjects: organism description > virus > adenovirus
CSHL Authors:
Communities: CSHL labs
CSHL labs > Roberts lab
Depositing User: Matt Covey
Date: 1978
Date Deposited: 12 Dec 2016 20:20
Last Modified: 12 Dec 2016 20:20
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