Protein-DNA Interactions at the Origin of Simian Virus 40 DNA Replication

Tjian, R. (1979) Protein-DNA Interactions at the Origin of Simian Virus 40 DNA Replication. Cold Spring Harb Symp Quant Biol, 43. pp. 655-662. ISSN 0091-7451

DOI: 10.1101/SQB.1979.043.01.073


The processes involved in initiating DNA replication have recently been studied with great success. The major advances have largely come from in vitro studies of simple bacteriophage systems such as those described in this volume (Meyer et al.; Eisenberg et al.; Godson; Schaller). The replication of more complex phages such as λ and of the bacterial host itself have also been examined in some detail (Messer et al.; Hirota et al.; Wickner; Hobom et al.; Furth et al.; all this volume). However, our knowledge of how higher eukaryotic cells initiate and control replication lags far behind. This is due partly to the difficulties of studying complex genomes and partly to the lack of replication-defective mutants to guide us through the maze of enzymatic reactions, which must be associated with the process of replication.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
organism description > virus > SV40
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1979
Date Deposited: 13 Dec 2016 17:54
Last Modified: 13 Dec 2016 17:54
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