Lane, D. P., Crawford, L. V. (1979) T Antigen Is Bound to a Host Protein in Sv40-Transformed Cells. Nature, 278 (5701). pp. 261-263. ISSN 0028-0836
Abstract
THE early region of the small DNA tumour virus, simian virus 40 (SV40), is known to code for at least two polypeptides, the t and T antigens (‘small t’ and ‘large T’). Both these polypeptides are expressed in cells transformed by the virus1–4, and the T antigen has been shown to be essential for both the initiation and maintenance of the transformed state5–9. We therefore need to know how this T protein interacts with components of the host cell in order to understand the mechanism of SV40-induced transformation. We report here that the T antigen in a line of SV40-transformed mouse cells forms an oligomeric complex with a specific cell coded protein.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organism description > virus > SV40 |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | 1979 |
| Date Deposited: | 16 May 2016 19:12 |
| Last Modified: | 16 May 2016 19:12 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32703 |
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