Gene conversion of the mating-type locus in Saccharomyces cerevisiae

Klar, A. J., Fogel, S., Lusnak, K. (July 1979) Gene conversion of the mating-type locus in Saccharomyces cerevisiae. Genetics, 92 (3). pp. 777-82. ISSN 0016-6731 (Print)0016-6731 (Linking)



Tetrad analysis of MATa/MAT alpha diploids of Saccharomyces cerevisiae generally yields 2 MATa:2MAT alpha meiotic products. About 1 to 1.8% of the tetrads yield aberrant segregations for this marker. Described here are experiments that determine whether the aberrant meiotic segregations at the mating-type locus are ascribable to gene conversions or to MAT switches, that is, to mating-type interconversions. Diploid strains incapable of switching MATa to MAT alpha, or the converse, nevertheless display changes of MATa to MAT alpha, or the reverse. These events must be attributed to gene conversion. Further, we suggest that MATa and MAT alpha alleles may represent nonhomologous sequences of DNA since they fail to display postmeiotic segregations.

Item Type: Paper
Uncontrolled Keywords: *Genes Meiosis Phenotype *Recombination, Genetic Saccharomyces cerevisiae/*genetics/physiology Spores, Fungal
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organs, tissues, organelles, cell types and functions > organelles, types and functions > meiosis
organism description > yeast
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: July 1979
Date Deposited: 12 May 2016 19:34
Last Modified: 12 May 2016 19:34
PMCID: PMC1214036
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