Otmakhov, N., Shirke, A. M., Malinow, R.
(June 1993)
Measuring the impact of probabilistic transmission on neuronal output.
Neuron, 10 (6).
pp. 1101-11.
ISSN 0896-6273 (Print)0896-6273 (Linking)
Abstract
We have investigated the impact of stochastic transmission on the input-output relations of neurons in hippocampal slices. A synaptic input that fires a cell has a significant trial-to-trial variability in amplitude, reflecting the probabilistic release of transmitter. By measuring miniature excitatory postsynaptic currents, we estimate that synchronous release of a few vesicles can fire a CA1 cell. The firing threshold and variability can be physiologically modulated. Different cell types have distinct firing thresholds and variabilities. Long-term potentiation (LTP) decreases trial-to-trial variability. If after LTP, the stimulus is reduced to produce a threshold response, the variability returns to that observed before LTP. Thus, for a threshold input, the trial-to-trial variability is maintained with LTP. This may be important for the proper functioning of a plastic nervous system.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Action Potentials
Animals
Evoked Potentials/drug effects
Hippocampus/*physiology
In Vitro Techniques
Mathematics
*Models, Neurological
Neurons/drug effects/*physiology
Probability
Pyramidal Tracts/*physiology
Rats
Stochastic Processes
Synapses/*physiology
Tetrodotoxin/pharmacology |
| Subjects: |
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Malinow lab |
| Depositing User: |
Matt Covey
|
| Date: |
June 1993 |
| Date Deposited: |
12 Apr 2016 19:44 |
| Last Modified: |
12 Apr 2016 19:44 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/32579 |
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