Wilson, A. C., Cleary, M. A., Lai, J. S., LaMarco, K., Peterson, M. G., Herr, W. (June 1993) Combinatorial control of transcription: the herpes simplex virus VP16-induced complex. Cold Spring Harb Symp Quant Biol, 58. pp. 167-78. ISSN 0091-7451 (Print)
Abstract
Common features of transcriptional regulation in multicellular organisms are the modular and combinatorial structure of cis-acting DNA sequences and trans-acting proteins. Promoters represent the cis-acting regulatory elements and consist of proximal and basal elements positioned near the transcriptional initiation site and enhancers, which can be located far from the transcriptional initiation site. These elements, especially enhancers, are in turn each composed of multiple modules or transcription factor binding sites that are arranged in combinations that specify a given pattern of transcriptional regulation. Transcription factors are also modular, frequently consisting of transcriptional activation domains, which interact with other proteins in the transcriptional machinery, and DNA-binding domains, which tether the activation domain to the appropriate promoter. The modularity of transcription factors is flexible; activation and DNA-binding modules can be exchanged between transcription factors, thereby creating chimeric molecules with new regulatory properties (Brent and Ptashne 1985).
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Animals Base Sequence Binding Sites DNA/genetics DNA-Binding Proteins/chemistry/genetics Gene Expression Regulation, Viral Herpes Simplex Virus Protein Vmw65/chemistry/ genetics Host Cell Factor C1 Humans Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Octamer Transcription Factor-1 Octamer Transcription Factor-2 Protein Conformation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Simplexvirus/ genetics Transcription Factors/chemistry/genetics Transcription, Genetic |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein organism description > virus > herpes simplex virus bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Herr lab |
| Depositing User: | Matt Covey |
| Date: | June 1993 |
| Date Deposited: | 21 Apr 2016 16:24 |
| Last Modified: | 21 Apr 2016 16:24 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32499 |
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