Telomeres, telomerase and senescence

Greider, C. W. (August 1990) Telomeres, telomerase and senescence. Bioessays, 12 (8). pp. 363-9. ISSN 0265-9247 (Print)0265-9247 (Linking)

DOI: 10.1002/bies.950120803


Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence Chromosomes/*physiology DNA Nucleotidylexotransferase/*metabolism *DNA Replication DNA-Directed DNA Polymerase/*metabolism Models, Genetic Molecular Sequence Data Mutation
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres
CSHL Authors:
Communities: CSHL labs > Greider lab
Depositing User: Matt Covey
Date: August 1990
Date Deposited: 09 Feb 2016 19:43
Last Modified: 09 Feb 2016 19:43
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