Greider, C. W. (August 1990) Telomeres, telomerase and senescence. Bioessays, 12 (8). pp. 363-9. ISSN 0265-9247 (Print)0265-9247 (Linking)
Abstract
Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Base Sequence Chromosomes/*physiology DNA Nucleotidylexotransferase/*metabolism *DNA Replication DNA-Directed DNA Polymerase/*metabolism Models, Genetic Molecular Sequence Data Mutation |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres |
| CSHL Authors: | |
| Communities: | CSHL labs > Greider lab |
| Depositing User: | Matt Covey |
| Date: | August 1990 |
| Date Deposited: | 09 Feb 2016 19:43 |
| Last Modified: | 09 Feb 2016 19:43 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32346 |
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