Dyson, N., Bernards, R., Friend, S. H., Gooding, L. R., Hassell, J. A., Major, E. O., Pipas, J. M., Vandyke, T., Harlow, E. (March 1990) Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol, 64 (3). pp. 1353-6. ISSN 0022-538X (Print)0022-538X (Linking)
Abstract
Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Animals *Antigens, Polyomavirus Transforming/analysis/genetics Haplorhini Humans Molecular Sequence Data *Nuclear Proteins Papio *Phosphoproteins/analysis/metabolism Polyomavirus/genetics/*immunology Protein Binding Retinoblastoma Protein Sequence Homology, Nucleic Acid |
| Subjects: | organism description > virus > adenovirus diseases & disorders > cancer > cancer types > retinoblastoma |
| CSHL Authors: | |
| Communities: | CSHL labs > Stillman lab |
| Depositing User: | Matt Covey |
| Date: | March 1990 |
| Date Deposited: | 30 Mar 2016 16:54 |
| Last Modified: | 30 Mar 2016 16:54 |
| PMCID: | PMC249255 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32305 |
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