Control of translation in adenovirus-infected cells

Mathews, M. B. (1990) Control of translation in adenovirus-infected cells. Enzyme, 44 (1-4). pp. 250-64. ISSN 0013-9432 (Print)0013-9432 (Linking)



The initiation of protein synthesis in adenovirus-infected cells is regulated during the late phase in two ways, which may be related. The overall translation rate is maintained by a small viral RNA, VA RNAI, which prevents the phosphorylation of initiation factor eIF-2 by a double-stranded RNA-activated protein kinase, DAI. In addition, the relative efficiency of translation of host cell and viral mRNA populations is regulated in the infected cell during the late phase such that viral mRNAs are selectively utilized. Three viral elements have been implicated in this process: the 5' leader present on most late viral mRNAs; the late protein, 100K; and VA RNA. This article reviews the mechanisms underlying these translational control phenomena.

Item Type: Paper
Uncontrolled Keywords: Adenoviridae/drug effects/*genetics Adenoviridae Infections/*genetics Animals Eukaryotic Initiation Factor-2 *Gene Expression Regulation, Viral Interferons/pharmacology Peptide Chain Initiation, Translational/genetics *Protein Biosynthesis Protein Kinases RNA, Small Nuclear eIF-2 Kinase
Subjects: organism description > virus > adenovirus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > translation
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1990
Date Deposited: 04 Apr 2016 19:44
Last Modified: 04 Apr 2016 19:44

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving