Mathews, M. B. (1990) Control of translation in adenovirus-infected cells. Enzyme, 44 (1-4). pp. 250-64. ISSN 0013-9432 (Print)0013-9432 (Linking)
Abstract
The initiation of protein synthesis in adenovirus-infected cells is regulated during the late phase in two ways, which may be related. The overall translation rate is maintained by a small viral RNA, VA RNAI, which prevents the phosphorylation of initiation factor eIF-2 by a double-stranded RNA-activated protein kinase, DAI. In addition, the relative efficiency of translation of host cell and viral mRNA populations is regulated in the infected cell during the late phase such that viral mRNAs are selectively utilized. Three viral elements have been implicated in this process: the 5' leader present on most late viral mRNAs; the late protein, 100K; and VA RNA. This article reviews the mechanisms underlying these translational control phenomena.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adenoviridae/drug effects/*genetics Adenoviridae Infections/*genetics Animals Eukaryotic Initiation Factor-2 *Gene Expression Regulation, Viral Interferons/pharmacology Peptide Chain Initiation, Translational/genetics *Protein Biosynthesis Protein Kinases RNA, Small Nuclear eIF-2 Kinase |
| Subjects: | organism description > virus > adenovirus bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > translation |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | 1990 |
| Date Deposited: | 04 Apr 2016 19:44 |
| Last Modified: | 04 Apr 2016 19:44 |
| URI: | https://repository.cshl.edu/id/eprint/32269 |
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