Malinow, R.
(May 1991)
Transmission between pairs of hippocampal slice neurons: quantal levels, oscillations, and LTP.
Science, 252 (5006).
pp. 722-4.
ISSN 0036-8075 (Print)0036-8075 (Linking)
Abstract
Long-term potentiation (LTP) of synaptic transmission after coincident pre- and postsynaptic activity is considered a cellular model of changes underlying learning and memory. In intact tissue, LTP has been observed only between populations of neurons, making analysis of mechanisms difficult. Transmission between individual pre- and postsynaptic hippocampal cells was studied, suggesting quantal amplitude distributions with little variability in quantal size. LTP between such pairs is manifested by large, persistent, and synapse-specific potentiation with a shift in amplitude distribution that suggests presynaptic changes. Oscillations in amplitude of transmission, apparently of presynaptic origin, are common and can be triggered by LTP.
| Item Type: |
Paper
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| Uncontrolled Keywords: |
Animals
Electric Conductivity
Electrophysiology
Hippocampus/*cytology
Kinetics
Membrane Potentials
Neurons/*physiology
Rats
Statistics as Topic
Synapses/*physiology
Synaptic Transmission/*physiology |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
Investigative techniques and equipment > electrophysiology > brain slice
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Malinow lab |
| Depositing User: |
Matt Covey
|
| Date: |
3 May 1991 |
| Date Deposited: |
09 Dec 2015 20:34 |
| Last Modified: |
09 Dec 2015 20:34 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/32165 |
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