Characterization of G1 and mitotic cyclins of budding yeast

Tyers, M., Fitch, I., Tokiwa, G., Dahmann, C., Nash, R., Linskens, M., Futcher, B. (1991) Characterization of G1 and mitotic cyclins of budding yeast. Cold Spring Harb Symp Quant Biol, 56. pp. 21-32. ISSN 0091-7451 (Print)0091-7451 (Linking)

DOI: 10.1101/SQB.1991.056.01.005


It has been known for a decade that in yeast, the CDC28 gene of Saccharomyces cerevisiae and the cdc2+ gene of Schizosaccharomyces pombe are needed at two points in their host's cell cycles: once in G1 phase, for commitment to division, and once again in mitosis (Nurse and Bissett 1981; Piggott et al. 1982). These two genes encode highly homologous proteins, which have proven to be the catalytic subunits of protein kinases (Reed et al. 1985; Simanis and Nurse 1986). The active protein kinase is a complex containing the Cdc28/cdc2 protein and a protein called a cyclin (Draetta et al. 1989). Other subunits may also be present (Brizuela et al. 1987.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Cyclins/genetics/*metabolism Genes, Fungal Interphase/genetics/*physiology Mitosis/genetics/*physiology Models, Biological Molecular Sequence Data Mutation Peptides/pharmacology Protein Kinases/genetics/metabolism Protein Tyrosine Phosphatases/metabolism Saccharomyces cerevisiae/*cytology/genetics/metabolism Sequence Homology, Nucleic Acid
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Cyclins
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Futcher lab
Depositing User: Matt Covey
Date: 1991
Date Deposited: 14 Jan 2016 15:12
Last Modified: 14 Jan 2016 15:12
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