Otazu, G. H., Chae, H. G., Albeanu, D. F. (September 2015) Cortical feedback decorrelates olfactory bulb output in awake mice. In: Association for Chemoreception Sciences (AChemS), 37th Annual Meeting, 22–25 April 2015, Bonita Springs, Florida.
Abstract
The olfactory bulb receives rich glutamatergic projections from the piriform cortex. However, the dynamics and importance of these feedback signals remain unknown. Here, we use multiphoton calcium imaging to monitor cortical feedback in the olfactory bulb of awake mice and further probe its impact on bulb output. Responses of feedback boutons were sparse, odor specific and often outlasted stimuli by several seconds. Odor presentation both enhanced and suppressed the activity of boutons. However, any given bouton responded with stereotypic polarity across multiple odors, preferring either enhancement or suppression. Feedback representations were locally diverse and differed in dynamics across bulb layers. Inactivation of piriform cortex increased odor responsiveness and pairwise similarity of mitral cells, but had little impact on tufted cells. We propose that cortical feedback differentially impacts the two output channels of the bulb by specifically decorrelating mitral cell responses to enable odor separation. Acknowledgements: NIH. FCOI Disclosure: None.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Additional Information: | Meeting Abstract |
| Subjects: | Publication Type > Meeting Abstract organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb |
| CSHL Authors: | |
| Communities: | CSHL labs > Albeanu lab |
| Depositing User: | Matt Covey |
| Date: | September 2015 |
| Date Deposited: | 20 Oct 2015 19:13 |
| Last Modified: | 22 Oct 2025 18:30 |
| URI: | https://repository.cshl.edu/id/eprint/31950 |
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