Dos Santos, L. I., Galvao-Filho, B., de Faria, P. C., Junqueira, C., Dutra, M. S., Teixeira, S. M., Rodrigues, M. M., Ritter, G., Bannard, O., Fearon, D. T., Antonelli, L. R., Gazzinelli, R. T. (March 2015) Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1. Cancer Immunol Immunother, 64 (3). pp. 311-23. ISSN 0340-7004
Abstract
The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8(+) T lymphocytes that efficiently prevent tumor development. However, the therapeutic effect of such a vaccine is limited. We also demonstrate that blockade of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) during vaccination enhances the frequency of NY-ESO-1-specific effector CD8(+) T cells producing IFN-gamma and promotes lymphocyte migration to the tumor infiltrate. As a result, therapy with CL-14-NY-ESO-1 together with anti-CTLA-4 is highly effective in controlling the development of an established melanoma.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Antigens, Neoplasm/administration & dosage/genetics/*immunology CD8-Positive T-Lymphocytes/*immunology/parasitology CTLA-4 Antigen/antagonists & inhibitors/*immunology Cancer Vaccines/*immunology Female Humans Immunotherapy/*methods Melanoma, Experimental/immunology/parasitology/*therapy Membrane Proteins/administration & dosage/genetics/*immunology Mice Mice, Inbred C57BL Recombinant Proteins/administration & dosage/genetics/immunology Trypanosoma cruzi/genetics/immunology |
| Subjects: | diseases & disorders > cancer organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Program > Signal Transduction CSHL labs > Fearon lab |
| Depositing User: | Matt Covey |
| Date: | March 2015 |
| Date Deposited: | 15 Oct 2015 20:37 |
| Last Modified: | 22 Nov 2024 13:37 |
| PMCID: | PMC11029141 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31928 |
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