Grueneberg, D. A., Natesan, S., Alexandre, C., Gilman, M. Z. (August 1992) Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science, 257 (5073). pp. 1089-95. ISSN 0036-8075 (Print)0036-8075 (Linking)
Abstract
Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA residues within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of specificity of action of homeodomain proteins in development.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Animals Base Sequence Binding Sites DNA/genetics/*metabolism DNA-Binding Proteins/chemistry/genetics/*metabolism/*pharmacology Drosophila/genetics *Drosophila Proteins Fungal Proteins/chemistry/pharmacology *Homeodomain Proteins Humans Minichromosome Maintenance 1 Protein Molecular Sequence Data Nuclear Proteins/*metabolism Saccharomyces cerevisiae/genetics Serum Response Factor Transcription Factors/chemistry/*metabolism/pharmacology Transfection |
| Subjects: | organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > homeodomain protein organism description > animal > mammal > primates > hominids > human |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | 21 August 1992 |
| Date Deposited: | 18 Sep 2015 15:06 |
| Last Modified: | 18 Sep 2015 15:06 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31864 |
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