Molecular characterization of the Schwann cell myelin protein, SMP: structural similarities within the immunoglobulin superfamily

Dulac, C., Tropak, M. B., Cameroncurry, P., Rossier, J., Marshak, D. R., Roder, J., Ledouarin, N. M. (February 1992) Molecular characterization of the Schwann cell myelin protein, SMP: structural similarities within the immunoglobulin superfamily. Neuron, 8 (2). pp. 323-334. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/1739462

DOI: 10.1016/0896-6273(92)90298-R

Abstract

The Schwann cell myelin protein (SMP), previously defined in quail and chick by a monoclonal antibody, is in vivo exclusively expressed by myelinating and nonmyelinating Schwann cells and oligodendrocytes. The isolation of the complete nucleotide sequence of SMP is reported here. The predicted polypeptide chain reveals that SMP is a transmembrane molecule of the immunoglobulin superfamily showing sequence similarities with several surface glycoproteins expressed in the nervous and immune systems. In spite of a 43.5% overall sequence identity between rat myelin-associated glycoprotein (MAG) and quail SMP, SMP does not seem to be the avian homolog of MAG, since their expression, regulation, and functions are significantly different. Unusual sequence arrangements shared by SMP, MAG, and two lymphoid antigens suggest the existence of a particular subgroup in the immunoglobulin superfamily.

Item Type:	Paper
Uncontrolled Keywords:	adhesion molecule n-cam nervous-system extracellular-matrix monoclonal-antibody binding-properties gene superfamily glycoprotein mag neural adhesion messenger-rnas
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > myelin basic protein organs, tissues, organelles, cell types and functions > cell types and functions > cell types > myelinating cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > myelinating cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > myelinating cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > schwann cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > schwann cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > schwann cells
CSHL Authors:	Marshak, Daniel R.
Communities:	CSHL labs
Depositing User:	Matt Covey
Date:	February 1992
Date Deposited:	23 Sep 2015 15:06
Last Modified:	23 Sep 2015 15:06
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/31839

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