Properties of synaptic transmission and the global stability of delayed activity states

Koulakov, A. A. (February 2001) Properties of synaptic transmission and the global stability of delayed activity states. Network, 12 (1). pp. 47-74. ISSN 0954-898X (Print)0954-898X (Linking)

DOI: 10.1080/net.


The influence of synaptic channel properties on the stability of delayed activity maintained by recurrent neural networks is studied. The duration of excitatory post-synaptic current (EPSC) is shown to be essential for the global stability of the delayed response. The NMDA receptor channel is a much more reliable mediator of the reverberating activity than the AMPA receptor, due to a longer EPSC. This allows one to interpret the deterioration of the working memory observed in NMDA channel blockade experiments. The key mechanism leading to the decay of the delayed activity originates in the unreliability of synaptic transmission. The optimum fluctuation of the synaptic currents leading to the decay is identified. The decay time is calculated analytically and the result is confirmed computationally.

Item Type: Paper
Uncontrolled Keywords: Action Potentials Animals Computer Simulation Humans Memory/ physiology Models, Neurological Nerve Net/physiology Prefrontal Cortex/physiology Rats Receptors, AMPA/physiology Receptors, N-Methyl-D-Aspartate/physiology Synaptic Transmission/ physiology Time Factors
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Koulakov lab
Depositing User: Matt Covey
Date: February 2001
Date Deposited: 22 Jul 2015 20:32
Last Modified: 22 Jul 2015 20:32
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