Karpanen, T., Egeblad, M., Karkkainen, M. J., Kubo, H., Yla-Herttuala, S., Jaattela, M., Alitalo, K. (March 2001) Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Research, 61 (5). pp. 1786-90. ISSN 0008-5472 (Print)0008-5472
Abstract
Many solid tumors produce vascular endothelial growth factor C (VEGF-C), and its receptor, VEGFR-3, is expressed in tumor blood vessels. To study the role of VEGF-C in tumorigenesis, we implanted MCF-7 human breast carcinoma cells overexpressing recombinant VEGF-C orthotopically into severe combined immunodeficient mice. VEGF-C increased tumor growth, but unlike VEGF, it had little effect on tumor angiogenesis. Instead, VEGF-C strongly promoted the growth of tumor-associated lymphatic vessels, which in the tumor periphery were commonly infiltrated with the tumor cells. These effects of VEGF-C were inhibited by a soluble VEGFR-3 fusion protein. Our data suggest that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGF-C and its receptor.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Breast Neoplasms/*blood supply/genetics/metabolism/pathology Cell Division/physiology Endothelial Growth Factors/antagonists & inhibitors/biosynthesis/genetics/*physiology Female Humans Immunoglobulins/biosynthesis/blood/genetics Lymphatic System/*pathology Mice Mice, SCID Neoplasm Transplantation Neovascularization, Pathologic/metabolism/*physiopathology Receptor Protein-Tyrosine Kinases/biosynthesis/blood/genetics Receptors, Growth Factor/biosynthesis/blood/genetics Recombinant Fusion Proteins/biosynthesis/blood/genetics Transfection Transplantation, Heterologous Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor Receptor-3 |
| Subjects: | diseases & disorders > cancer > cancer types > breast cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Vascular endothelial growth factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Egeblad lab |
| Depositing User: | Matt Covey |
| Date: | 1 March 2001 |
| Date Deposited: | 05 Dec 2014 16:42 |
| Last Modified: | 05 Dec 2014 16:42 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30954 |
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